CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain
Functional Family [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial

Enzyme Information

2.7.11.4
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase.
based on mapping to UniProt Q00972
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] = ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate.
-!- Has no activating compound but is specific for its substrate. -!- A mitochondrial enzyme associated with the branched-chain 2-oxoacid dehydrogenase complex. -!- Phosphorylation inactivates EC 1.2.4.4. -!- Formerly EC 2.7.1.115.

UniProtKB Entries (1)

Q00972
BCKD_RAT
Rattus norvegicus
[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial

PDB Structure

PDB 3TZ4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase.
Tso, S.C., Qi, X., Gui, W.J., Chuang, J.L., Morlock, L.K., Wallace, A.L., Ahmed, K., Laxman, S., Campeau, P.M., Lee, B.H., Hutson, S.M., Tu, B.P., Williams, N.S., Tambar, U.K., Wynn, R.M., Chuang, D.T.
Proc.Natl.Acad.Sci.USA
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