CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.40 | Beta Barrel | |
2.40.10 | Thrombin, subunit H | |
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
Superfamily | Trypsin-like serine proteases |
Functional Family | Mannan-binding lectin serine protease 2 |
Enzyme Information
3.4.21.104 |
Mannan-binding lectin-associated serine protease-2.
based on mapping to UniProt O00187
Selective cleavage after Arg-223 in complement component C2 (-Ser- Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).
-!- Mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine, on a wide range of microbial surfaces and is able to initiate activation of the lectin pathway of complement. -!- Displays C1s-like esterolytic activity (cf. EC 3.4.21.42). -!- It also cleaves C4 and C2 with efficiencies that are relatively higher than those of EC 3.4.21.42. -!- Belongs to peptidase family S1A.
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UniProtKB Entries (1)
O00187 |
MASP2_HUMAN
Homo sapiens
Mannan-binding lectin serine protease 2
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PDB Structure
PDB | 3TVJ |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2.
J.Biol.Chem.
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