CATH Domain 3tu7H01

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Superfamily	Trypsin-like serine proteases
Functional Family	Prothrombin

3.4.21.5

Thrombin.

based on mapping to UniProt P00734

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.

-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

P00734	THRB_HUMAN Homo sapiens Prothrombin
P09945	HIRV2_HIRME Hirudo medicinalis Hirudin variant-2

PDB	3TU7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Molecular design and structure-activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664. Das, J., Kimball, S.D., Hall, S.E., Han, W.C., Iwanowicz, E., Lin, J., Moquin, R.V., Reid, J.A., Sack, J.S., Malley, M.F., Chang, C.Y., Chong, S., Wang-Iverson, D.B., Roberts, D.G., Seiler, S.M., Schumacher, W.A., Ogletree, M.L. Bioorg.Med.Chem.Lett.