CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.700 | Peptidase G1 |
Domain Context
CATH Clusters
| Superfamily | Peptidase G1 |
| Functional Family |
Enzyme Information
| 3.4.23.19 |
Aspergillopepsin II.
based on mapping to UniProt P24665
Preferential cleavage in B chain of insulin: 3-Asn-|-Gln-4, 13-Gly-|-Ala- 14, and 26-Tyr-|-Thr-27.
-!- Isolated from Aspergillus niger var. macrosporus, distinct from aspergillopepsin I in specificity and insensitivity to pepstatin. -!- Belongs to peptidase family A4. -!- Formerly EC 3.4.23.6.
|
UniProtKB Entries (1)
| P24665 |
PRTA_ASPNG
Aspergillus niger
Aspergillopepsin-2
|
PDB Structure
| PDB | 3TRS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The crystal structure of an intermediate dimer of aspergilloglutamic peptidase that mimics the enzyme-activation product complex produced upon autoproteolysis.
J.Biochem.
|
