CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.8 | Helicase, Ruva Protein; domain 3 | |
1.10.8.100 | Ribosomal RNA adenine dimethylase-like, domain 2 |
Domain Context
CATH Clusters
Superfamily | Ribosomal RNA adenine dimethylase-like, domain 2 |
Functional Family | Ribosomal RNA small subunit methyltransferase A |
Enzyme Information
2.1.1.182 |
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase.
based on mapping to UniProt P06992
4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)- dimethyladenine(1519) in 16S rRNA.
-!- KsgA introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine(1518) and adenine(1519) in 16S rRNA. -!- Strains lacking the methylase are resistant to kasugamycin. -!- Formerly EC 2.1.1.48.
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UniProtKB Entries (1)
P06992 |
RSMA_ECOLI
Escherichia coli K-12
Ribosomal RNA small subunit methyltransferase A
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PDB Structure
PDB | 3TPZ |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Control of Substrate Specificity by a Single Active Site Residue of the KsgA Methyltransferase.
Biochemistry
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