CATH Domain 3tm0A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1200	Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2
	3.90.1200.10	Aminoglycoside phosphotransferase (APH), C-terminal lobe

Domain Context

CATH Clusters

Superfamily	3.90.1200.10
Functional Family

Enzyme Information

2.7.1.95

Kanamycin kinase.

based on mapping to UniProt P0A3Y5

ATP + kanamycin = ADP + kanamycin 3'-phosphate.

-!- Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. -!- An enzyme from Pseudomonas aeruginosa also acts on butirosin.

UniProtKB Entries (1)

P0A3Y5

KKA3_ENTFL

Enterococcus faecalis

Aminoglycoside 3'-phosphotransferase

PDB Structure

PDB	3TM0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis of APH(3')-IIIa-mediated resistance to N1-substituted aminoglycoside antibiotics. Fong, D.H., Berghuis, A.M. Antimicrob.Agents Chemother.