CATH Domain 3th8A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1180	Undecaprenyl pyrophosphate synthetase
	3.40.1180.10	Decaprenyl diphosphate synthase-like

Domain Context

CATH Clusters

Superfamily	Decaprenyl diphosphate synthase-like
Functional Family	(2E,6E)-farnesyl-diphosphate-specific ditrans,polycis-undecaprenyl-diphosphate synthase

Enzyme Information

2.5.1.31

Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl- diphosphate specific).

based on mapping to UniProt P60472

(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.

-!- Undecaprenyl pyrophosphate synthase catalyzes the consecutive condensation reactions of a farnesyl diphosphate with eight isopentenyl diphosphates, in which new cis-double bonds are formed, to generate undecaprenyl diphosphate that serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall.

UniProtKB Entries (1)

P60472

UPPS_ECOLI

Escherichia coli K-12

Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

PDB Structure

PDB	3TH8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. Zhang, Y., Lin, F.-Y., Li, K., Zhu, W., Liu, Y.L., Cao, R., Pang, R., Lee, E., Axelson, J., Hensler, M., Wang, K., Molohon, K.J., Wang, Y., Mitchell, D.A., Nizet, V., Oldfield, E. ACS Med Chem Lett