CATH Domain 3tguI00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.210	Cytochrome Bc1 Complex; Chain I
	2.10.210.10	Cytochrome Bc1 Complex; Chain I

Domain Context

CATH Clusters

Superfamily	Cytochrome Bc1 Complex; Chain I
Functional Family	Cytochrome b-c1 complex subunit Rieske, mitochondrial

Enzyme Information

7.1.1.8

Quinol--cytochrome-c reductase.

based on mapping to UniProt Q5ZLR5

Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2).

-!- The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. -!- It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. -!- The mammalian enzyme contains cytochromes b-562, b-566 and c(1), and a 2-iron ferredoxin. -!- Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non- cytoplasmic compartment (cf. EC 1.6.99.3). -!- Formerly EC 1.10.2.2.

UniProtKB Entries (1)

D0VX29

D0VX29_CHICK

Gallus gallus

Mitochondrial ubiquinol-cytochrome-c reductase complex core protein 2

PDB Structure

PDB	3TGU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Computational discovery of picomolar Q(o) site inhibitors of cytochrome bc1 complex. Hao, G.F., Wang, F., Li, H., Zhu, X.L., Yang, W.C., Huang, L.S., Wu, J.W., Berry, E.A., Yang, G.F. J.Am.Chem.Soc.