CATH Domain 3tgeA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase

Enzyme Information

3.1.4.35

3',5'-cyclic-GMP phosphodiesterase.

based on mapping to UniProt O76074

Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

PDE5A_HUMAN

Homo sapiens

CGMP-specific 3',5'-cyclic phosphodiesterase

PDB Structure

PDB	3TGE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Investigation of the pyrazinones as PDE5 inhibitors: Evaluation of regioisomeric projections into the solvent region. Hughes, R.O., Maddux, T., Joseph Rogier, D., Lu, S., Walker, J.K., Jon Jacobsen, E., Rumsey, J.M., Zheng, Y., Macinnes, A., Bond, B.R., Han, S. Bioorg.Med.Chem.Lett.