CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.630 | Aminopeptidase |
|
3.40.630.30 | Gcn5-related N-acetyltransferase (GNAT) |
Domain Context
CATH Clusters
| Superfamily | 3.40.630.30 |
| Functional Family | Dopamine N-acetyltransferase |
Enzyme Information
| 2.3.1.87 |
Aralkylamine N-acetyltransferase.
based on mapping to UniProt Q94521
Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine.
-!- Narrow specificity toward 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. -!- This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4). -!- Differs from EC 2.3.1.5.
|
UniProtKB Entries (1)
| Q94521 |
DNAT_DROME
Drosophila melanogaster
Dopamine N-acetyltransferase
|
PDB Structure
| PDB | 3TE4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of the dopamine N-acetyltransferase-acetyl-CoA complex provides insights into the catalytic mechanism
Biochem.J.
|
