CATH Domain 3tc7A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family

Enzyme Information

4.1.1.48

Indole-3-glycerol-phosphate synthase.

based on mapping to UniProt Q06121

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C- (3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.

-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).

UniProtKB Entries (1)

Q06121

TRPC_SACS2

Saccharolobus solfataricus P2

Indole-3-glycerol phosphate synthase

PDB Structure

PDB	3TC7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design. Bjelic, S., Kipnis, Y., Wang, L., Pianowski, Z., Vorobiev, S., Su, M., Seetharaman, J., Xiao, R., Kornhaber, G., Hunt, J.F., Tong, L., Hilvert, D., Baker, D. J.Mol.Biol.