CATH Domain 3t0cA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.210

Domain Context

CATH Clusters

Superfamily	3.20.20.210
Functional Family

Enzyme Information

2.1.1.14

5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.

based on mapping to UniProt Q8CWX6

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.

-!- Requires phosphate. -!- The enzyme from Escherichia coli also requires a reducing system. -!- Unlike EC 2.1.1.13 this enzyme does not contain cobalamin.

UniProtKB Entries (1)

Q8CWX6

METE_STRMU

Streptococcus mutans UA159

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

PDB Structure

PDB	3T0C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structures of Cobalamin-Independent Methionine Synthase (MetE) from Streptococcus mutans: A Dynamic Zinc-Inversion Model Fu, T.M., Almqvist, J., Liang, Y.H., Li, L., Huang, Y., Su, X.D. J.Mol.Biol.