CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.60 | 4-Layer Sandwich |
|
3.60.120 | Anthranilate synthase |
|
3.60.120.10 | Anthranilate synthase |
Domain Context
CATH Clusters
| Superfamily | Anthranilate synthase |
| Functional Family | Salicylate synthase |
Enzyme Information
| 4.2.99.21 |
Isochorismate lyase.
based on mapping to UniProt P9WFX1
Isochorismate = salicylate + pyruvate.
-!- This enzyme is part of the pathway of salicylate formation from chorismate, and forms an integral part of pathways that produce salicylate-derived siderophores, such as pyochelin and yersiniabactin.
|
| 5.4.99.5 |
Chorismate mutase.
based on mapping to UniProt P9WFX1
Chorismate = prephenate.
|
| 5.4.4.2 |
Isochorismate synthase.
based on mapping to UniProt P9WFX1
Chorismate = isochorismate.
-!- The reaction is reversible. -!- Formerly EC 5.4.99.6.
|
UniProtKB Entries (1)
| P9WFX1 |
MBTI_MYCTU
Mycobacterium tuberculosis H37Rv
Salicylate synthase
|
PDB Structure
| PDB | 3ST6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry
|
