CATH Domain 3sr5X00

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.430	Dihydrofolate Reductase, subunit A
	3.40.430.10	Dihydrofolate Reductase, subunit A

Superfamily	Dihydrofolate Reductase, subunit A
Functional Family	Dihydrofolate reductase

1.5.1.3

Dihydrofolate reductase.

based on mapping to UniProt P0A017

5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.

-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

DYR_STAAU

Staphylococcus aureus

Dihydrofolate reductase

PDB	3SR5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Li, X., Hilgers, M., Cunningham, M., Chen, Z., Trzoss, M., Zhang, J., Kohnen, L., Lam, T., Creighton, C., G C, K., Nelson, K., Kwan, B., Stidham, M., Brown-Driver, V., Shaw, K.J., Finn, J. Bioorg.Med.Chem.Lett.