CATH Domain 3sqoP01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.80	Peptidase S8 propeptide/proteinase inhibitor I9

Domain Context

CATH Clusters

Superfamily	Peptidase S8 propeptide/proteinase inhibitor I9
Functional Family	Proprotein convertase subtilisin/kexin type 9

Enzyme Information

3.4.21.-

Serine endopeptidases.

based on mapping to UniProt Q8NBP7

UniProtKB Entries (1)

PCSK9_HUMAN

Homo sapiens

Proprotein convertase subtilisin/kexin type 9

PDB Structure

PDB	3SQO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates. Liang, H., Chaparro-Riggers, J., Strop, P., Geng, T., Sutton, J.E., Tsai, D., Bai, L., Abdiche, Y., Dilley, J., Yu, J., Wu, S., Chin, S.M., Lee, N.A., Rossi, A., Lin, J.C., Rajpal, A., Pons, J., Shelton, D.L. J.Pharmacol.Exp.Ther.