CATH Domain 3soaA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2

Enzyme Information

2.7.11.17

Calcium/calmodulin-dependent protein kinase.

based on mapping to UniProt Q9UQM7

ATP + a protein = ADP + a phosphoprotein.

-!- Requires calmodulin. -!- A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light-chains and the microtubule- associated tau protein. -!- Not identical with EC 2.7.11.18 or EC 2.7.11.26. -!- Formerly EC 2.7.1.120 and EC 2.7.1.123.

UniProtKB Entries (1)

Q9UQM7

KCC2A_HUMAN

Homo sapiens

Calcium/calmodulin-dependent protein kinase type II subunit alpha

PDB Structure

PDB	3SOA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca(2+)/Calmodulin- Dependent Kinase II Holoenzyme. Chao, L.H., Stratton, M.M., Lee, I.H., Rosenberg, O.S., Levitz, J., Mandell, D.J., Kortemme, T., Groves, J.T., Schulman, H., Kuriyan, J. Cell(Cambridge,Mass.)