CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.40 | Beta Barrel | |
2.40.10 | Thrombin, subunit H | |
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
Superfamily | Trypsin-like serine proteases |
Functional Family | Transmembrane serine protease 7 |
Enzyme Information
3.4.21.109 |
Matriptase.
based on mapping to UniProt Q9Y5Y6
Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position.
-!- This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis. -!- Can activate hepatocyte growth factor/scattering factor (HGF/SF) by cleavage of the two-chain form at an Arg residue to give active alpha- and beta-HGF, but it does not activate plasminogen, which shares high homology with HGF. -!- Can also activate urokinase plasminogen activator (uPA), which initiates the matrix-degrading peptidase cascade. -!- Belongs to peptidase family S1A.
|
UniProtKB Entries (1)
Q9Y5Y6 |
ST14_HUMAN
Homo sapiens
Suppressor of tumorigenicity 14 protein
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PDB Structure
PDB | 3SO3 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
A reverse binding motif that contributes to specific protease inhibition by antibodies.
J.Mol.Biol.
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