CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.20 | Ubiquitin-like (UB roll) |
|
3.10.20.30 | Beta-grasp domain |
Domain Context
CATH Clusters
| Superfamily | 3.10.20.30 |
| Functional Family | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial |
Enzyme Information
| 1.3.5.1 |
Succinate dehydrogenase (quinone).
based on mapping to UniProt Q007T0
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.
|
UniProtKB Entries (1)
| A5GZW8 |
DHSD_PIG
Sus scrofa
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
|
PDB Structure
| PDB | 3SFD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature.
Protein Cell
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