CATH Domain 3sd5A05

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1070	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5
	1.10.1070.11	Phosphatidylinositol 3-/4-kinase, catalytic domain

Domain Context

CATH Clusters

Superfamily	Phosphatidylinositol 3-/4-kinase, catalytic domain
Functional Family	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Enzyme Information

2.7.1.153	Phosphatidylinositol-4,5-bisphosphate 3-kinase. based on mapping to UniProt P48736 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate. -!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt P48736 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

PK3CG_HUMAN

Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PDB Structure

PDB	3SD5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor. Maira, S.M., Pecchi, S., Huang, A., Burger, M., Knapp, M., Sterker, D., Schnell, C., Guthy, D., Nagel, T., Wiesmann, M., Brachmann, S., Fritsch, C., Dorsch, M., Chene, P., Shoemaker, K., De Pover, A., Menezes, D., Martiny-Baron, G., Fabbro, D., Wilson, C.J., Schlegel, R., Hofmann, F., Garcia-Echeverria, C., Sellers, W.R., Voliva, C.F. Mol.Cancer Ther.