CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.10 | Jelly Rolls |
Domain Context
CATH Clusters
| Superfamily | Jelly Rolls |
| Functional Family | (S)-2-hydroxypropylphosphonic acid epoxidase |
Enzyme Information
| 1.11.1.23 |
(S)-2-hydroxypropylphosphonic acid epoxidase.
based on mapping to UniProt Q56185
(S)-2-hydroxypropylphosphonate + H(2)O(2) = (1R,2S)-1,2- epoxypropylphosphonate + 2 H(2)O.
-!- This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species. -!- Contains non heme iron that forms a iron(IV)-oxo (ferryl) complex with hydrogen peroxide, which functions as a proton abstractor from the substrate. -!- Formerly EC 1.14.19.7.
|
UniProtKB Entries (1)
| Q56185 |
HPPE_STRWE
Streptomyces wedmorensis
(S)-2-hydroxypropylphosphonic acid epoxidase
|
PDB Structure
| PDB | 3SCF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis.
J.Am.Chem.Soc.
|
