CATH Domain 3s9iA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1220	Malate Synthase G; Chain: A; Domain 4
	1.20.1220.12	Malate synthase, domain III

Domain Context

CATH Clusters

Superfamily	Malate synthase, domain III
Functional Family

Enzyme Information

2.3.3.9

Malate synthase.

based on mapping to UniProt P9WK17

Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.

-!- The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. -!- Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO(2). -!- Formerly EC 4.1.3.2.

UniProtKB Entries (1)

P9WK17

MASZ_MYCTU

Mycobacterium tuberculosis H37Rv

Malate synthase G

PDB Structure

PDB	3S9I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Krieger, I.V., Freundlich, J.S., Gawandi, V.B., Roberts, J.P., Gawandi, V.B., Sun, Q., Owen, J.L., Fraile, M.T., Huss, S.I., Lavandera, J.L., Ioerger, T.R., Sacchettini, J.C. Chem.Biol.