CATH Domain 3s22A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.710	Beta-lactamase
	3.40.710.10	DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily	DD-peptidase/beta-lactamase superfamily
Functional Family	Beta-lactamase

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt P24735

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P24735

AMPC_PSEAE

Pseudomonas aeruginosa PAO1

Beta-lactamase

PDB Structure

PDB	3S22
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Side chain SAR of bicyclic Beta-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712 Chen, H., Blizzard, T.A., Kim, S., Wu, J., Young, K., Park, Y.W., Ogawa, A.M., Raghoobar, S., Painter, R.E., Wisniewski, D., Hairston, N., Fitzgerald, P., Sharma, N., Scapin, G., Lu, J., Hermes, J., Hammond, M.L. Bioorg.Med.Chem.Lett.