CATH Domain 3s0nA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Complement factor D

Enzyme Information

3.4.21.39

Chymase.

based on mapping to UniProt P23946

Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.

-!- In mast cell granules. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

CMA1_HUMAN

Homo sapiens

Chymase

PDB Structure

PDB	3S0N
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Benzimidazolone as potent chymase inhibitor: Modulation of reactive metabolite formation in the hydrophobic (P(1)) region. Lo, H.Y., Nemoto, P.A., Kim, J.M., Hao, M.H., Qian, K.C., Farrow, N.A., Albaugh, D.R., Fowler, D.M., Schneiderman, R.D., Michael August, E., Martin, L., Hill-Drzewi, M., Pullen, S.S., Takahashi, H., De Lombaert, S. Bioorg.Med.Chem.Lett.