CATH Classification

Domain Context

CATH Clusters

Superfamily Jelly Rolls
Functional Family

Enzyme Information

1.13.11.72
2-hydroxyethylphosphonate dioxygenase.
based on mapping to UniProt Q5IW40
2-hydroxyethylphosphonate + O(2) = hydroxymethylphosphonate + formate.
-!- Isolated from some bacteria including Streptomyces hygroscopicus and Streptomyces viridochromogenes. -!- The pro-R hydrogen at C-2 of the ethyl group is retained by the formate ion. -!- Any stereochemistry at C-1 of the ethyl group is lost. -!- One atom from dioxygen is present in each product. -!- Involved in phosphinothricin biosynthesis.

UniProtKB Entries (1)

Q5IW40
HEPD_STRVT
Streptomyces viridochromogenes DSM 40736
2-hydroxyethylphosphonate dioxygenase

PDB Structure

PDB 3RZZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase.
Peck, S.C., Cooke, H.A., Cicchillo, R.M., Malova, P., Hammerschmidt, F., Nair, S.K., van der Donk, W.A.
Biochemistry
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