CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.60 | Sandwich | |
2.60.120 | Jelly Rolls | |
2.60.120.590 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
Domain Context
CATH Clusters
Superfamily | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
Functional Family | DNA oxidative demethylase ALKBH2 |
Enzyme Information
1.14.11.33 |
DNA oxidative demethylase.
based on mapping to UniProt Q6NS38
DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2).
-!- Activity is slightly stimulated by ascorbate. -!- Catalyzes oxidative demethylation of the DNA base lesions N(1)- methyladenine, N(3)-methylcytosine, N(1)-methylguanine, and N(3)- methylthymine. -!- It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA.
|
UniProtKB Entries (1)
Q6NS38 |
ALKB2_HUMAN
Homo sapiens
DNA oxidative demethylase ALKBH2
|
PDB Structure
PDB | 3RZM |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Duplex interrogation by a direct DNA repair protein in search of base damage
Nat.Struct.Mol.Biol.
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