CATH Domain 3rzhA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.590	Alpha-ketoglutarate-dependent dioxygenase AlkB-like

Domain Context

CATH Clusters

Superfamily	Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Functional Family	DNA oxidative demethylase ALKBH2

Enzyme Information

1.14.11.33

DNA oxidative demethylase.

based on mapping to UniProt Q6NS38

DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2).

-!- Activity is slightly stimulated by ascorbate. -!- Catalyzes oxidative demethylation of the DNA base lesions N(1)- methyladenine, N(3)-methylcytosine, N(1)-methylguanine, and N(3)- methylthymine. -!- It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA.

UniProtKB Entries (1)

Q6NS38

ALKB2_HUMAN

Homo sapiens

DNA oxidative demethylase ALKBH2

PDB Structure

PDB	3RZH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Duplex interrogation by a direct DNA repair protein in search of base damage Yi, C., Chen, B., Qi, B., Zhang, W., Jia, G., Zhang, L., Li, C.J., Dinner, A.R., Yang, C.G., He, C. Nat.Struct.Mol.Biol.