CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.640 | Myeloperoxidase, subunit C |
|
1.10.640.10 | Haem peroxidase domain superfamily, animal type |
Domain Context
CATH Clusters
| Superfamily | Haem peroxidase domain superfamily, animal type |
| Functional Family | Prostaglandin G/H synthase 2 |
Enzyme Information
| 1.14.99.1 |
Prostaglandin-endoperoxide synthase.
based on mapping to UniProt Q05769
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
-!- Acts both as a dioxygenase and as a peroxidase.
|
UniProtKB Entries (1)
| Q05769 |
PGH2_MOUSE
Mus musculus
Prostaglandin G/H synthase 2
|
PDB Structure
| PDB | 3RR3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2.
Nat.Chem.Biol.
|