CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family |
Enzyme Information
| 1.14.13.113 |
FAD-dependent urate hydroxylase.
based on mapping to UniProt A6T923
Urate + NADH + O(2) = 5-hydroxyisourate + NAD(+) + H(2)O.
-!- The reaction is part of the purine catabolic pathway in the bacterium Klebsiella pneumoniae. -!- The enzyme is different from EC 1.7.3.3, found in most plants, which produces hydrogen peroxide. -!- The product of the enzyme is a substrate for EC 3.5.2.17.
|
UniProtKB Entries (1)
| A6T923 |
HPXO_KLEP7
Klebsiella pneumoniae subsp. pneumoniae MGH 78578
FAD-dependent urate hydroxylase
|
PDB Structure
| PDB | 3RP6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and Mechanistic Studies of HpxO, a Novel Flavin Adenine Dinucleotide-Dependent Urate Oxidase from Klebsiella pneumoniae.
Biochemistry
|
