CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1190 | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase |
|
3.40.1190.20 | Ribokinase |
Domain Context
CATH Clusters
| Superfamily | 3.40.1190.20 |
| Functional Family | Ketohexokinase |
Enzyme Information
| 2.7.1.3 |
Ketohexokinase.
based on mapping to UniProt P50053
ATP + D-fructose = ADP + D-fructose 1-phosphate.
-!- D-sorbose, D-agatose and 5-dehydro-D-fructose also act as acceptors.
|
UniProtKB Entries (1)
| P50053 |
KHK_HUMAN
Homo sapiens
Ketohexokinase
|
PDB Structure
| PDB | 3RO4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors.
Bioorg.Med.Chem.Lett.
|
