CATH Domain 3rm8A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.50	Chitinase A; domain 3
	3.10.50.10

Domain Context

CATH Clusters

Superfamily	3.10.50.10
Functional Family	Chitinase 3-like 1

Enzyme Information

3.2.1.14

Chitinase.

based on mapping to UniProt Q9BZP6

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.

-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

Q9BZP6

CHIA_HUMAN

Homo sapiens

Acidic mammalian chitinase

PDB Structure

PDB	3RM8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification and Characterization of Acidic Mammalian Chitinase Inhibitors Cole, D.C., Olland, A.M., Jacob, J., Brooks, J., Bursavich, M.G., Czerwinski, R., Declercq, C., Johnson, M., Joseph-McCarthy, D., Ellingboe, J.W., Lin, L., Nowak, P., Presman, E., Strand, J., Tam, A., Williams, C.M.M., Yao, S., Tsao, D.H.H., Fitz, L.J. J.Med.Chem.