CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.8.1040
Functional Family

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q0PAS1
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q0PAS1
CBF2_CAMJE
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Putative peptidyl-prolyl cis-trans isomerase Cbf2

PDB Structure

PDB 3RFW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The virulence factor PEB4 and the periplasmic protein Cj1289 are two structurally-related SurA-like chaperones in the human pathogen Campylobacter jejuni
Kale, A., Phansopa, C., Suwannachart, C., Craven, C.J., Rafferty, J., Kelly, D.J.
To be Published
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