CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Uronate dehydrogenase |
Enzyme Information
| 1.1.1.203 |
Uronate dehydrogenase.
based on mapping to UniProt Q7CRQ0
(1) Beta-D-galacturonate + NAD(+) = D-galactaro-1,5-lactone + NADH. (2) Beta-D-glucuronate + NAD(+) = D-glucaro-1,5-lactone + NADH.
-!- The enzyme, characterized from the bacterium Agrobacterium fabrum, participates in oxidative degradation pathways for galacturonate and glucuronate. -!- The enzyme can only accept the beta anomeric form of the substrate. -!- The 1,5 lactone product is rather stable at cytosolic pH and does not hydrolyze spontaneously at a substantial rate. -!- Formerly EC 1.2.1.35.
|
UniProtKB Entries (1)
| Q7CRQ0 |
URODH_AGRFC
Agrobacterium fabrum str. C58
Uronate dehydrogenase
|
PDB Structure
| PDB | 3RFT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of Uronate Dehydrogenase from Agrobacterium tumefaciens.
J.Biol.Chem.
|