CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family MAP kinase-activated protein kinase 2

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P49137
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P49137
MAPK2_HUMAN
Homo sapiens
MAP kinase-activated protein kinase 2

PDB Structure

PDB 3R30
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based lead identification of ATP-competitive MK2 inhibitors.
Barf, T., Kaptein, A., Wilde, S., Heijden, R., Someren, R., Demont, D., Schultz-Fademrecht, C., Versteegh, J., Zeeland, M., Seegers, N., Kazemier, B., Kar, B., Hoek, M., Roos, J., Klop, H., Smeets, R., Hofstra, C., Hornberg, J., Oubrie, A.
Bioorg.Med.Chem.Lett.