CATH Domain 3qwaA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.180	Quinone Oxidoreductase; Chain A, domain 1
	3.90.180.10	Medium-chain alcohol dehydrogenases, catalytic domain

Domain Context

CATH Clusters

Superfamily	Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family	Quinone oxidoreductase 1

Enzyme Information

1.6.5.5

NADPH:quinone reductase.

based on mapping to UniProt P38230

NADPH + 2 quinone = NADP(+) + 2 semiquinone.

-!- Specific for NADPH. -!- Catalyzes the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates. -!- Dicoumarol (cf. EC 1.6.5.2) and nitrofurantoin are competitive inhibitors with respect to the quinone substrate. -!- The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O(2). -!- Abundant in the lens of the eye of some mammalian species.

UniProtKB Entries (1)

P38230

QOR_YEAST

Saccharomyces cerevisiae S288C

Probable quinone oxidoreductase

PDB Structure

PDB	3QWA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural insights into the cofactor-assisted substrate recognition of yeast quinone oxidoreductase Zta1 Guo, P.C., Ma, X.X., Bao, Z.Z., Ma, J.D., Chen, Y., Zhou, C.Z. J.Struct.Biol.