CATH Domain 3qsaA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.970	Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3
	1.20.970.10	Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C

Domain Context

CATH Clusters

Superfamily	Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C
Functional Family	Anthranilate phosphoribosyltransferase

Enzyme Information

2.4.2.18

Anthranilate phosphoribosyltransferase.

based on mapping to UniProt P9WFX5

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.

-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).

UniProtKB Entries (1)

P9WFX5

TRPD_MYCTU

Mycobacterium tuberculosis H37Rv

Anthranilate phosphoribosyltransferase

PDB Structure

PDB	3QSA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inhibition of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase by blocking of an active site entrance tunnel. Castell, A., Short, L.F., Evans, G., Bulloch, E.M., Cookson, T., Parker, E., Lee, C., Baker, E.N., Lott, J.S. To be Published