CATH Domain 3qquA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P08069

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08069

IGF1R_HUMAN

Homo sapiens

Insulin-like growth factor 1 receptor

PDB Structure

PDB	3QQU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors. Buchanan, J.L., Newcomb, J.R., Carney, D.P., Chaffee, S.C., Chai, L., Cupples, R., Epstein, L.F., Gallant, P., Gu, Y., Harmange, J.C., Hodge, K., Houk, B.E., Huang, X., Jona, J., Joseph, S., Jun, H.T., Kumar, R., Li, C., Lu, J., Menges, T., Morrison, M.J., Novak, P.M., van der Plas, S., Radinsky, R., Rose, P.E., Sawant, S., Sun, J.R., Surapaneni, S., Turci, S.M., Xu, K., Yanez, E., Zhao, H., Zhu, X. Bioorg.Med.Chem.Lett.