CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.510 | Transferase(Phosphotransferase); domain 1 |
|
1.10.510.10 | Transferase(Phosphotransferase) domain 1 |
Domain Context
CATH Clusters
| Superfamily | Transferase(Phosphotransferase) domain 1 |
| Functional Family | G protein-coupled receptor kinase |
Enzyme Information
| 2.7.11.14 |
Rhodopsin kinase.
based on mapping to UniProt P28327
ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.
-!- Acts on the bleached or activated form of rhodopsin. -!- Also phosphorylates the beta-adrenergic receptor, but more slowly. -!- Does not act on casein, histones or phosphovitin. -!- Inhibited by Zn(2+) and digitonin (cf. EC 2.7.11.15 and EC 2.7.11.16). -!- Formerly EC 2.7.1.97 and EC 2.7.1.125.
|
UniProtKB Entries (1)
| P28327 |
RK_BOVIN
Bos taurus
Rhodopsin kinase
|
PDB Structure
| PDB | 3QC9 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Activation of G Protein-Coupled Receptor Kinase 1 Involves Interactions between Its N-Terminal Region and Its Kinase Domain.
Biochemistry
|
