CATH Domain 3q5hA01

Superfamily	Acid Proteases
Functional Family	renin

3.4.23.15

Renin.

based on mapping to UniProt P00797

Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.

-!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.15 and EC 3.4.99.19.

RENI_HUMAN

Homo sapiens

Renin

PDB	3Q5H
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. Jia, L., Simpson, R.D., Yuan, J., Xu, Z., Zhao, W., Cacatian, S., Tice, C.M., Guo, J., Ishchenko, A., Singh, S.B., Wu, Z., McKeever, B.M., Bukhtiyarov, Y., Johnson, J.A., Doe, C.P., Harrison, R.K., McGeehan, G.M., Dillard, L.W., Baldwin, J.J., Claremon, D.A. ACS Med Chem Lett