CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Receptor protein serine/threonine kinase

Enzyme Information

2.7.11.30
Receptor protein serine/threonine kinase.
based on mapping to UniProt Q04771
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q04771
ACVR1_HUMAN
Homo sapiens
Activin receptor type-1

PDB Structure

PDB 3Q4U
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A new class of small molecule inhibitor of BMP signaling.
Sanvitale, C.E., Kerr, G., Chaikuad, A., Ramel, M.C., Mohedas, A.H., Reichert, S., Wang, Y., Triffitt, J.T., Cuny, G.D., Yu, P.B., Hill, C.S., Bullock, A.N.
Plos One