CATH Domain 3q2hA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.390	Collagenase (Catalytic Domain)
	3.40.390.10	Collagenase (Catalytic Domain)

Domain Context

CATH Clusters

Superfamily	Collagenase (Catalytic Domain)
Functional Family	A disintegrin and metalloproteinase with thrombospondin motifs 1

Enzyme Information

3.4.24.-

Metalloendopeptidases.

based on mapping to UniProt Q9UHI8

UniProtKB Entries (1)

ATS1_HUMAN

Homo sapiens

A disintegrin and metalloproteinase with thrombospondin motifs 1

PDB Structure

PDB	3Q2H
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis De Savi, C., Pape, A., Cumming, J.G., Ting, A., Smith, P.D., Burrows, J.N., Mills, M., Davies, C., Lamont, S., Milne, D., Cook, C., Moore, P., Sawyer, Y., Gerhardt, S. Bioorg.Med.Chem.Lett.