CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.50 | Alpha/alpha barrel |
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1.50.10 | Glycosyltransferase |
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1.50.10.20 |
Domain Context
CATH Clusters
Superfamily | 1.50.10.20 |
Functional Family | Geranylgeranyl transferase type-2 subunit beta |
Enzyme Information
2.5.1.60 |
Protein geranylgeranyltransferase type II.
based on mapping to UniProt Q08603
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl- protein + diphosphate.
-!- This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the protein prenyltransferase family of enzymes. -!- Attaches geranylgeranyl groups to two C-terminal cysteines in Ras- related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs. -!- Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). -!- Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion.
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UniProtKB Entries (1)
Q08603 |
PGTB2_RAT
Rattus norvegicus
Geranylgeranyl transferase type-2 subunit beta
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PDB Structure
PDB | 3PZ1 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure-Guided Development of Selective RabGGTase Inhibitors.
Angew.Chem.Int.Ed.Engl.
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