CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.20 | Single Sheet |
|
2.20.130 | S-adenosyl-L-methionine-dependent methyltransferases |
|
2.20.130.10 | CAC2371-like domains |
Domain Context
CATH Clusters
| Superfamily | CAC2371-like domains |
| Functional Family |
Enzyme Information
| 2.1.1.235 |
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase.
based on mapping to UniProt P95748
2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D- glucopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,6- dideoxy-alpha-D-glucopyranose.
-!- The enzyme is involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin, which is produced by the bacterium Streptomyces fradiae.
|
UniProtKB Entries (1)
| P95748 |
TYLM1_STRFR
Streptomyces fradiae
DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase
|
PDB Structure
| PDB | 3PX3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Molecular Architecture of TylM1 from Streptomyces fradiae: An N,N-Dimethyltransferase Involved in the Production of dTDP-d-mycaminose .
Biochemistry
|
