CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.50 | Rossmann fold |
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3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
Superfamily | Vaccinia Virus protein VP39 |
Functional Family | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase |
Enzyme Information
2.1.1.235 |
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase.
based on mapping to UniProt P95748
2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D- glucopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,6- dideoxy-alpha-D-glucopyranose.
-!- The enzyme is involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin, which is produced by the bacterium Streptomyces fradiae.
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UniProtKB Entries (1)
P95748 |
TYLM1_STRFR
Streptomyces fradiae
DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase
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PDB Structure
PDB | 3PX2 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Molecular Architecture of TylM1 from Streptomyces fradiae: An N,N-Dimethyltransferase Involved in the Production of dTDP-d-mycaminose .
Biochemistry
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