CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.10 | Thrombin, subunit H |
|
2.40.10.330 |
Domain Context
CATH Clusters
| Superfamily | 2.40.10.330 |
| Functional Family |
Enzyme Information
| 5.2.1.8 |
Peptidylprolyl isomerase.
based on mapping to UniProt Q58235
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
|
UniProtKB Entries (1)
| Q58235 |
FKBP2_METJA
Methanocaldococcus jannaschii DSM 2661
Putative FKBP-type peptidyl-prolyl cis-trans isomerase MJ0825
|
PDB Structure
| PDB | 3PRB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Analysis of Protein Folding by the Long-Chain Archaeal Chaperone FKBP26.
J.Mol.Biol.
|
