CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.310 | TATA-Binding Protein |
|
3.30.310.50 | Alpha-D-phosphohexomutase, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Alpha-D-phosphohexomutase, C-terminal domain |
| Functional Family | Phosphoglucosamine mutase |
Enzyme Information
| 5.4.2.10 |
Phosphoglucosamine mutase.
based on mapping to UniProt Q81VN7
Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate.
-!- The enzyme is involved in the pathway for bacterial cell-wall peptidoglycan and lipopolysaccharide biosyntheses, being an essential step in the pathway for UDP-N-acetylglucosamine biosynthesis. -!- The enzyme from Escherichia coli is activated by phosphorylation and can be autophosphorylated in vitro by alpha-D-glucosamine 1,6- bisphosphate, which is an intermediate in the reaction, alpha-D- glucose 1,6-bisphosphate or ATP. -!- It can also catalyze the interconversion of alpha-D-glucose 1-phosphate and alpha-D-glucose 6-phosphate, although at a much lower rate.
|
UniProtKB Entries (1)
| Q81VN7 |
GLMM_BACAN
Bacillus anthracis
Phosphoglucosamine mutase
|
PDB Structure
| PDB | 3PDK |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of Bacillus anthracis Phosphoglucosamine Mutase, an Enzyme in the Peptidoglycan Biosynthetic Pathway.
J.Bacteriol.
|
