CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase S8 propeptide/proteinase inhibitor I9
Functional Family Proprotein convertase subtilisin/kexin type 9

Enzyme Information

3.4.21.-
Serine endopeptidases.
based on mapping to UniProt Q8NBP7

UniProtKB Entries (1)

Q8NBP7
PCSK9_HUMAN
Homo sapiens
Proprotein convertase subtilisin/kexin type 9

PDB Structure

PDB 3P5B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Lo Surdo, P., Bottomley, M.J., Calzetta, A., Settembre, E.C., Cirillo, A., Pandit, S., Ni, Y.G., Hubbard, B., Sitlani, A., Carfi, A.
Embo Rep.