CATH Domain 3p4rA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.58	Methane Monooxygenase Hydroxylase; Chain G, domain 1
	1.20.58.100	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
Functional Family	Succinate dehydrogenase flavoprotein subunit (SdhA)

Enzyme Information

1.3.5.4

Fumarate reductase (quinol).

based on mapping to UniProt P00363

Succinate + a quinone = fumarate + a quinol.

-!- The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. -!- The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.

UniProtKB Entries (1)

P0AC47

FRDB_ECOLI

Escherichia coli K-12

Fumarate reductase iron-sulfur subunit

PDB Structure

PDB	3P4R
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Geometric restraint drives on- and off-pathway catalysis by the Escherichia coli menaquinol:fumarate reductase. Tomasiak, T.M., Archuleta, T.L., Andrell, J., Luna-Chavez, C., Davis, T.A., Sarwar, M., Ham, A.J., McDonald, W.H., Yankovskaya, V., Stern, H.A., Johnston, J.N., Maklashina, E., Cecchini, G., Iverson, T.M. J.Biol.Chem.