CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase domain
Functional Family

Enzyme Information

2.4.2.44
S-methyl-5'-thioinosine phosphorylase.
based on mapping to UniProt Q9HZK1
S-methyl-5'-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio- alpha-D-ribose 1-phosphate.
-!- No activity with S-methyl-5'-thioadenosine. -!- The catabolism of of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 3.5.4.31) and phosphorolysis to hypoxanthine.

UniProtKB Entries (1)

Q9HZK1
MTIP_PSEAE
Pseudomonas aeruginosa PAO1
S-methyl-5'-thioinosine phosphorylase

PDB Structure

PDB 3OZB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing.
Guan, R., Ho, M.C., Almo, S.C., Schramm, V.L.
Biochemistry
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