CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.1550 | Archaeal tRNA CCA-adding enzyme catalytic domain |
Domain Context
CATH Clusters
| Superfamily | Archaeal tRNA CCA-adding enzyme catalytic domain |
| Functional Family |
Enzyme Information
| 2.7.7.72 |
CCA tRNA nucleotidyltransferase.
based on mapping to UniProt O28126
A tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate.
-!- The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3' CCA sequence. -!- The CCA sequence is added to the tRNA precursor by stepwise nucleotide addition performed by a single enzyme that is ubiquitous in all living organisms. -!- Although the enzyme has the option of releasing the product after each addition, it prefers to stay bound to the product and proceed with the next addition. -!- Formerly EC 2.7.7.21 and EC 2.7.7.25.
|
UniProtKB Entries (1)
| O28126 |
CCA_ARCFU
Archaeoglobus fulgidus DSM 4304
CCA-adding enzyme
|
PDB Structure
| PDB | 3OVB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
How the CCA-Adding Enzyme Selects Adenine over Cytosine at Position 76 of tRNA.
Science
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