CATH Domain 3ouhA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.620	q2cbj1_9rhob like domain

Domain Context

CATH Clusters

Superfamily	q2cbj1_9rhob like domain
Functional Family	Egl nine homolog 1

Enzyme Information

1.14.11.29

Hypoxia-inducible factor-proline dioxygenase.

based on mapping to UniProt Q9GZT9

Hypoxia-inducible factor-L-proline + 2-oxoglutarate + O(2) = hypoxia- inducible factor-trans-4-hydroxy-L-proline + succinate + CO(2).

-!- Contains iron, and requires ascorbate. -!- Specifically hydroxylates a proline residue in HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction. -!- The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.

UniProtKB Entries (1)

Q9GZT9

EGLN1_HUMAN

Homo sapiens

Egl nine homolog 1

PDB Structure

PDB	3OUH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues. Rosen, M.D., Venkatesan, H., Peltier, H.M., Bembenek, S.D., Kanelakis, K.C., Zhao, L.X., Leonard, B.E., Hocutt, F.M., Wu, X., Palomino, H.L., Brondstetter, T.I., Haugh, P.V., Cagnon, L., Yan, W., Liotta, L.A., Young, A., Mirzadegan, T., Shankley, N.P., Barrett, T.D., Rabinowitz, M.H. ACS Med Chem Lett